Dr Andrew R. Harper
MRCP DPhil
Physician-scientist with expertise in human genetics and clinical development
Publications
2021
[34] Rare variant contribution to human disease in 281,104 UK Biobank exomes
Wang Q*, Dhindsa RS*, Carss K*, Harper AR, …, Petrovski S
[33] Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity
Harper AR, Goel A, Grace C, …, Watkins H
[32] Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect
Tadros R*, Francis C*, Xu X*, Vermeer AMC*, Harper AR, …, Bezzina CR
2020
[30] Secondary findings in inherited heart conditions: a genotype-first feasibility study to assess phenotype, behavioural and psychosocial outcomes
Ormondroyd E, Harper AR, Thomson KL, …, Watkins H
[29] Human essentiality genes and targeted oncology therapies
Harper AR, McDermott U, Petrovski S
[28] Whole-genome sequencing of patients with rare diseases in a national health system
NIHR BioResource Rare Disease collaborators
[27] Whole-genome sequencing of a sporadic primary immunodeficiency cohort
NIHR BioResource Rare Disease collaborators
[26] Data-driven modelling of mutational hotspots and in-silico predictors in hypertrophic cardiomyopathy
Waring A, Harper AR, … , Farrall M
[25] Reevaluation of the South Asian MYBPC3Δ25bp Intronic Deletion in Hypertrophic Cardiomyopathy
Harper AR, Bowman M, …, Watkins H, Thomson KL
2019
[24] Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM registry
Neubauer S, …, Harper AR, …, Kramer CM
[23] Outcome following heart transplant assessment in adults with congenital heart disease
Crossland DS, Jansen K, Parry, G, Harper AR, …, Coats L
[22] Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield
Thomson KL, Ormondroyd E, Harper AR, …, Watkins H
[21] Association of Titin-Truncating Genetic Variants With Life-threatening Cardiac Arrhythmias in Patients With Dilated Cardiomyopathy and Implanted Defibrillators
Corden B, … , Harper AR, …, Ware JS
[20] Germline selection shapes human mitochondrial DNA diversity
NIHR BioResource Rare Disease collaborators
2018
[19] Heart failure with preserved ejection fraction
Harper AR, Patel H, Lyon AR
2017
[18] Cardiomyopathies
Chan K, Harper AR, Ashrafian H, Yavari A
[17] Remote monitoring for heart failure: the story moves on
Harper AR, Cowie MR
[16] Clinical information has low sensitivity for postmortem diagnosis of heart valve disease.
Coffey S, Harper AR, Cairns BJ, Roberts IS, Prendergast BD
[15] Delivering Clinical Grade Sequencing and Genetic Test Interpretation for Cardiovascular Medicine
Harper AR, Parikh VN, Goldfeder RL, Caleshu C, Ashley EA
2016
[14] Sacubitril/valsartan: clinical evidence from PARADIGM-HF
Harper AR, Bakhai A
[13] Chronic activation of γ2 AMPK induces obesity and reduces β cell function
Yavari A, …, Harper AR, … , Watkins H, Ashrafian H
[12] Late Subannular Aortic Root Rupture Following Transcatheter Aortic Valve Implantation Presenting as ST Elevation Myocardial Infarction.
Harper AR, Dawkins S, Newton JD
2015
[11] Protective alleles and modifier variants in human health and disease
Harper AR, Nayee S, Topol EJ
[10] Resistance of Dynamin-related protein 1 Oligomers to Disassembly Impairs Mitophagy Resulting in Myocardial Inflammation and Heart failure.
Cahill TJ, …, Harper AR, …, Ashrafian H
2014
2013
[8] Is alternative cardiac surgery an option in adults with congenital heart disease referred for thoracic organ transplantation?
Harper AR, Crossland DS, Perri G, O’Sullivan JJ, Chaudhari MP, Schueler S, Griselli M, Hasan A
[7] Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass
Harper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, Avery PJ, Keavney BD
[6] Drug eluting stents versus bare metal stents in primary PCI
Kunadian V, Harper AR, Bawamia B, Zaman A
[5] Platelet function monitoring and clopidogrel
Harper AR, Price MJ
2012
[4] Pharmacogenomics in clinical practice and drug development
Harper AR, Topol EJ
[3] Genomic risk models improve prediction of longitudinal lipid levels in children and young adults
Wineinger NE, Harper AR, Libiger O, Srinivasan SR, Chen W, Berenson GS, Schork NJ
[2] Critical evaluation of the efficacy and tolerability of azilsartan
De Caterina AR, Harper AR, Cuculi F
[1] Tetralogy of fallot with double aortic arch
Harper AR, Dai M, Prabhatha RM
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